Hi friend,

When I started Blueprint, I was a broken-down 42-year-old. Sugar cereal and soda as a kid, a decade of chronic depression, and 20 years of sleep deprivation. I was overweight, my joints hurt, and I was losing my hair.

Five years later, I'm surprised. Really surprised.

Here is a sampling of my biomarkers:

Muscle: 98th percentile (all men)
Fat: 98th percentile optimal (all men)
Bone mineral density: 99th percentile (all ages)
Resting heart rate: elite athlete level
Fertility: top 99th percentile (all men)
Sexual function (NTE): 99th percentile (all men)
Blood pressure: lower than 90% of 18 year olds
Vascular function: late teen / early 20s
VEGF: top 1% of healthy individuals
Sleep: top quartile for 18–29 year olds
Telomeres: equivalent to a 10–15 year old
Telomere regenerating rate: 12 year old
Epigenetic speed of aging: 0.48
Grip strength: top 5% of all ages
Blood glucose: lower than 98% of 18–25 year olds
Blood sugar control: better than 99% of 18–25 year olds

There is the richest person in the world, and the fastest. I wondered, could someone quantifiably be the healthiest? That's probably impossible to know right now, but it hasn't stopped me from trying.

I share this to give you hope that you can meaningfully change your health for the better. There are of course limitations with today's science, but more can be accomplished than most people think.

I started Blueprint as I think we may be the first generation who won't die. That doesn't mean immortality. It means that with advancements in AI, we may soon begin to extend our lifespans far enough into the horizon that we will begin asking the question: just how long can we live?

If you're new to this game of health, don't worry. I made disastrous health decisions in life until I was 42 and my body has bounced back. No matter your situation, you can too.

I'm going to share everything my team and I have learned over the past few years, spending millions of dollars researching, experimenting and measuring. We've made the mistakes for you.

Know that we are also hard at work to make all of this easier, more accessible and fun.

We are living in the most exciting time in human history. The future is probably cooler than anything we can imagine. Our goal is to get there, together.

The move is to band together and rebuild our societal systems that acknowledge that existence is the highest virtue.

We can start with ourselves.

Go to bed on time.
Exercise daily.
Eat well.
Drop the bad habits.
Help others do the same.

──

Blueprint — Most emails suck. We're trying not to.

Don't Die, Bryan Johnson

Originally published in Bryan Johnson's Blueprint newsletter (December 28, 2025). This content is for informational purposes only and is not medical advice. Consult your healthcare provider before starting any new wellness protocol.

My Results After 5 Years of Blueprint